Mechanisms of organophosphate neurotoxicity
نویسندگان
چکیده
منابع مشابه
MECHANISMS OF PREDICTION AND POTENTIAL CAUSATION OF ORGANOPHOSPHATE INDUCED DELAYED NEUROTOXICITY by Nichole
Serine esterases are inhibited by dialkyl fluorinated aminophosphonate (FAP) compounds of general formula, (RO)2P(O)C(CF3)2NHS(O)2C6H5, where R = alkyl. It has been hypothesized that the active site serine of the esterase covalently attaches to the phosphoryl moiety of the FAP compound, resulting in formation of a dialkyl phosphate adduct that can age by net loss of an R-group. However, this me...
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ژورنال
عنوان ژورنال: Current Opinion in Toxicology
سال: 2021
ISSN: 2468-2020
DOI: 10.1016/j.cotox.2021.04.002